目   次

原著論文要旨

Chemistry

Inorganic and Physical

STM observation of thia[11]hetero helicene on gold(111) and gold(110) surface.---------  1

Masahiro Taniguchi, Hiroko Nakagawa (中川弘子), Akihiko Yamagishi,

Kohichi Yamada (山田紘一)

 

113Sn-113mIn generator with a glass beads column.-------------------------------------------------------------------  2

Kunie Teranishi(寺西邦江), Yasuko Yamaashi(山足安子),

and Yoshiaki Maruyama(丸山芳明)

 

Organic

Antioxidative Activity of Allium victorialis L. Extracts------------------------------------------------------------------  3

Yoshiaki Shirataki (白瀧 義明), Noboru Motohashi, Satoru Tani(谷 覺),

Katsuyoshi Sunaga(須永 克佳),Hiroshi Sakagami, Kazue Satoh, Hideki Nakashima, Taisei Kanamoto, Kristina Wolfard and Joseph Molnar

 

Effects of Prenylflavanones from Sophora Species on Growth and Activation of Mouse Macrophage-like Cell Line             4

Miyuki Tashiro(田代 美由樹) , Fumika Suzuki, Yoshiaki Shirataki (白瀧 義明) ,

Yoshiko Yokote, Kiso Akahane, Noboru Motohashi, Mariko Ishihara,

Yi Jiang and Hiroshi Sakagami,

 

Stilbene Derivatives from Two Species of Gnetaceae-------------------------------------------------------------------  5

Ibrahim Iliya, Toshiyuki Tanaka, Munekazu Iinuma, Zulfiqur Ali, Miyuki Furusawa,

Ken-ichi Nakaya, Yoshiaki Shirataki (白瀧 義明) , Jin Murata and Dedy Darnaed

 

 

 

 

Inhibitory Effects of Echinoisoflavanone and Sophoraisoflavanone D in Sophora chrysophylla Seem. on Copper Ion-Induced protein Oxidative Modification of Mouse Brain Homogenate In Vitro.........................................................  6

Shizuo Toda and Yoshiaki Shirataki (白瀧 義明)

 

Lipid Membrane Perturbation Caused by Some Isoflavones and Phenothiazines, and The Activity of These Compounds as Inhibitors of Multidrug Resistance----------------------------------------------------------------------------------------------------------  7

Krystyna Michalak, Andrzej B. Hendrich, Olga Wesolowska, Andrzej Pola,

Barbara Lania-Pietrzak, Noboru Motohashi,

Yoshiaki Shirataki (白瀧 義明)  and Joseph Molnarr

 

Stilbene Oligomers in Roots of Sophora moorcroftiana------------------------------------------------------------------  8

Yoshiaki Shirataki (白瀧 義明) , Toshiyuki Tanaka, Masayoshi Ohyama,

Shizuo Toda and Munekazu Iinuma

 

Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts     9

Noboru Motohashi, Yoshiaki Shirataki (白瀧 義明) , Masami Kawase (河瀬 雅美) ,

Satoru Tani(谷 覺), Hiroshi Sakagaami, Kazue Satoh, Teruo Kurihara, Hideki Nakashima, Ilona Mucsi , Andreas Varga and Joseph Molnar

 

Differential interaction of Sophora isoflavonoids with lipid bilayers--------------------------------------------  10

Andrzej B. Hendrich, Rafal Malon, Andrzej Pola, Yoshiaki Shirataki(白瀧 義明)

Noboru Motohashi and Krystyna Michalak

 

Effects of Isoflavones from Sophora Species on the Growth and Activation of a Mouse Macrophage-like Cell Line              11

Miyuki Tashiro(田代 美由樹) , Fumika Suzuki, Yoshiaki Shirataki (白瀧 義明) ,

Yoshiko Yokote, Kiso Akahane, Noboru Motohashi, Mariko Ishihara,

Kazue Satoh and Hiroshi Sakagami,

 

Inhibitory Effects of Isoflavones in Sophora moorcroftiana on Lipid Peroxidation

by Superoxide--------------------------------------------------------------------------------------------------------------------------------------------  12

Shizuo Toda and Yoshiaki Shirataki (白瀧 義明)

Reactivity of 2-Methylene-1,3-dicarbonyl Compounds. 1,3-Dipolar Cycloaddition Reaction with Nitrile Oxide.         13

Masashige Yamauchi(山内昌茂)

 

The Influence of Ligand Side Chain on the Enantioselectivity of Lewis Acid Catalyzed Diels-Alder Reactions              14

Masashige Yamauchi(山内昌茂), Kazuhiro Itai (板井和広) and Yuko Honda(本田裕子)

 

New Method for the Synthesis of Nitriles from O-Arylaldoximes with ZrCl4------------------------------------- 15

Chiho Tsuji(辻 千穂), Etsuko Miyazawa(宮沢悦子), Takeshi Sakamoto(坂本武史),

and Yasuo Kikugawa(菊川靖雄)

 

Introduction of a Hydroxy Group at the Para Position and N-Iodophenylation of N-Arylamides Using Phenyliodine(III) Bis(trifluoroacetate)--------------------------------------------------------------------------------------------------------------------------------------- 16

Naoki Itoh(伊藤直樹), Takeshi Sakamoto(坂本武史), Etsuko Miyazawa(宮沢悦子),

 and Yasuo Kikugawa(菊川靖雄)

 

3,5-Dibenzoyl-1,4-dihydropyridines: Synthesis and MDR Reversal in Tumor Cells-------------------   17

Masami Kawase(河瀬雅美), Anamik Shah, Harsukh Gaveriya, Noboru Motohashi,

Hiroshi Sakagami, Andreas Varga, and Joseph Molnar

 

Interaction between 3,4-dihydropyridines and ampicillin, and erythromycin on different E. coli strains      18

Gyorgyi Gunics, Sandor Farkas, Noboru Motohashi, Anamik Shah, Gaveriya Harsukh, Masami Kawase(河瀬雅美), and Joseph Molnar

 

Partial purification of cytotoxic substances from Moxa extract---------------------------------------------------  19

Ikusuke Hatsukari, Naoko Hitosugi, Rie Ohno, Shinichi Nakamura,

Satoshi Mizukami, Hiroshi Nagasaka, Isao Matsumoto, Hirotaka Kikuchi,

Hirofumi Nishikawa, Masaru Niitsu(新津勝), Masami Kawase(河瀬雅美),

Takaharu Negoro, Kazue Satoh, Hideki Nakashima and Hiroshi Sakagami

 

 

 

Interaction between various resistance modifiers and apoptosis inducer

12H-Benzo[a]phenothiazine------------------------------------------------------------------------------------------------------------------  20

Ilona Mucsi, Andreas Varga, Masami Kawase(河瀬雅美),

Noboru Motohashi and Joseph Molnar

 

Preparations of heterospirostanols and their pharmacological activities--------------------------------  21

Hanh-Ji Quan, Jyunichi Koyanagi(小柳順一), Koichi Ohmori, Shinichi Uesato,

Tetsuaki Tsuchido, Setsuo Saito(齋藤節生)*

 

Analytical

Mass Spectrometric Separation and Determination of N1,N12-Diacetylspermine in the Urine of Cancer Patients            22

Masaki Kobayashi(小林正樹) , Keijiro Samejima(鮫島啓二郎) ,

Kyoko Hiramatsu, and Masao Kawakita

 

Simultaneous Determination of Endogenous and Orally Administered 15N-Labeled Polyamines in Rat Organs                23

Yong Ji Xu(許 泳吉), Takeshi Hara(原 健), Keijiro Samejima(鮫島啓二郎),

Hitomi Sasaki(佐々木ひとみ), Masaru Niitsu(新津 勝)

 

 

Biochemistry/Molecular Biology

IF3, a novel cell-differentiation factor, highly expressed in murine liver and ovary. ----------  24

Hiroshi Mano(真野 博), Sachie Nakatani, Rika Aoyagi, Rina Ishii, Yuka Iwai,

Nanako Shimoda, Yuko Jincho, Hitoshi Hiura, Minako Hirose, Chikako Mochizuki,

Motoko Yuri, Ryang Hyock Im, Ulala Funada-Wada, Masahiro Wada(和田政裕).

 

Presence and Features of Fatty Acyl-CoA Binding Activity of Rat Hepatic Peroxisomes-----  25

Fumie Hashimoto(橋本フミ惠)and Hidenori Hayashi(林 秀徳)

 

Inhibition of cell growth through inactivation of eukaryotic translation initiation factor 5A (eIF5A) by deoxyspergualin   26

K. Nishimura, Y. Ohki, T. Fukuchi-Shimogori, K. Sakata, K. Saiga, T. Beppu (別府 隆信),

A Shirahata(白幡 晶), K. Kashiwagi and K. Igarashi

Polyamine structural effects on the induction and stabilization of liquid crystalline DNA : potential applications to DNA packaging, gene therapy and polyamine therapeutics-----------------------------------------------------------------  27

M. Saminathan, T. Thomas, A Shirahata(白幡 晶), C. K. S. Pillai and T. J. Thomas

 

 

 

 

Pharmaceutical

Targeting of salicylate to skin and muscle following topical injections in rats------------------------  28

Daisuke Yoshida(吉田大介), Tetsuya Hasegawa(長谷川哲也),

Kenji Sugibayashi(杉林堅次)

 

水晶発振子を用いた薬物のin vitro皮膚透過迅速測定法に関する検討Rapid measurement of in vitro skin permeation of a drug using quartz crystal microbalance-------------------------------------------------------------------------------------------------------  29

渡邉哲也(Tetsuya Watanabe)1,長谷川哲也(Tetsuya Hasegawa),高橋秀和,石橋卓也,

古沢宏幸,岡畑恵雄,杉林堅次(Kenji Sugibayashi)

 

Utility of MTT assay in three-dimensional cultured human skin model as an alternative for Draize skin irritation test: Approach using diffusion law of irritant in skin and toxicokinetics-toxicodynamics correlation-----------------------  30

Tetsuya Watanabe(渡邉哲也), Tetsuya Hasegawa(長谷川哲也),

Hidekazu Takahashi, Takuya Ishibashi, Hiroshi Itagaki, Kenji Sugibayashi(杉林堅次)

 

Kinetic analysis on the in vitro cytotoxicity using Living Skin Equivalent for ranking the toxic potential of dermal irritants                32

Kenji Sugibayashi(杉林堅次), Tetsuya Watanabe(渡邉哲也),

Tetsuya Hasegawa(長谷川哲也), Hidekazu Takahashi, Takuya Ishibashi

 

Bromocriptine Reverses P-Glycoprotein-mediated Multidrug Resistance in Tumor Cells---  33

Nobuaki Shiraki, Keiko Okamura, Jin Tokunaga, Takafumi Ohmura,

Kazuto Yasuda, Takeo Kawaguchi (川口健夫), Akinobu Hamada, Masahiro Nakano

 

 

N-acetyltransferase 2 genotype-related sulfapyridine acetylation and its adverse events....  34

Tanigawara Y, Kita T, Aoyama N, Gobara M, Komada F(駒田富佐夫), Sakai T, Kasuga M, Hatanaka H, Sakaeda T, Okumura K.

 

Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression            36

Takara K, Sakaeda T, Tanigawara Y, Nishiguchi K, Ohmoto N, Horinouchi M,

Komada F(駒田 富佐夫), Ohnishi N, Yokoyama T, Okumura K.

 

In Vitro Skin Permeation of Morphine Hydrochloride during the Finite Application of Penetration-Enhancing System Containing Water, Ethanol and l-Menthol-----------------------------------------------------------------------------------------------------------------  37

Yasunori Morimoto(森本雍憲), Yoshio Wada,

Toshinobu Seki(関 俊暢), and Kenji Sugibayashi(杉林堅次)

 

Effects of Particle Size, Helium Gas Pressure and Microparticle Dose on the Plasma Concentration of Indomethacin after Bombardment of Indomethacin-Loaded Poly-L-Lactic Acid Microspheres Using a HeliosTM Gun System  38

Masaki Uchida(内田昌希), Hideshi Natsume(夏目秀視), Daisuke Kobayashi(小林大介),

Kenji Sugibayashi(杉林堅次), and Yasunori Morimoto(森本雍憲)

 

Introduction of poly-L-lactic acid microspheres into the skin using supersonic flow: effects of helium gas pressure, particle size and microparticle dose on the amount introduced into hairless rat skin-------------------------------------------  39

Masaki Uchida(内田昌希), Yi Jin, Hideshi Natsume(夏目秀視),

Daisuke Kobayashi(小林大介), Kenji Sugibayashi(杉林堅次),

and Yasunori Morimoto(森本雍憲)

 

The Enhancing Effect of a Triethanolamine-Ethanol-Isopropyl Myristate Mixed System on the Skin Permeation of Acidic Drugs         41

Liang Fang(方 亮), Yoichi Kobayashi , Sachihiko Numajiri(沼尻幸彦),

Daisuke Kobayashi(小林大介), Kenji Sugibayashi(杉林堅次),

and Yasunori Morimoto(森本雍憲)

 

Analysis of Transient and Reversible Effects of Poly-L-Arginine on the in vivo nasal absorption of FITC-dextran in rats         42

Kazuo Ohtake(大竹一男), Hideshi Natsume(夏目秀視), Hideo Ueda(上田秀雄),

Yasunori Morimoto(森本雍憲)

 

Fast-Disintegration Oral Tablets Having Sustained Release Property-----------------------------------------  43

Yi Jin, Hideki Ohkuma(大熊英樹), Hua Wang, Hideshi Natsume(夏目秀視),

Kenji Sugibayashi(杉林堅次), and Yasunori Morimoto(森本雍憲)

 

 

Clinical Pharmacy

Overlapping of the Clinically Significant Adverse Reactions of Drugs

in the Poly-pharmacy --------------------------------------------------------------------------------------------------------------------------------- 44

Toshinari Endo(遠藤敏成), Nao Watanabe(渡辺 直), Ken-ichi Goto, Nobuaki Kutsuma,

 Fusao Komada(駒田富佐夫), Yukiya Saitoh(齋藤侑也), Daisuke Kobayashi(小林大介)

and Yasunori Morimoto(森本雍憲)

 

High Performance Liquid Chromatography for Routine Monitoring of Serum Flecainide----  45

Rei Nakagawa(中川 励), Masato Homma, Keisuke Koga, Iwao Yamaguchi,

Daisuke Kobayashi(小林大介), Yasunori Morimoto(森本雍憲), Yukinao Kohda

 

Current Situation of the Additional Severe Adverse Effects of Marketed Medicine----------- 46

Daisuke Kobayashi(小林大介) , Nobuaki Kutsuma, Megumi Nakayama, Atsushi Ukon,

Yuko Sashida(佐次田優子), Toshinari Endo(遠藤敏成), Hideo Ueda(上田秀雄),

Sachihiko Numajiri(沼尻幸彦), Fusao Komada(駒田富佐夫), Yukiya Saitoh(齋藤侑也), and Yasunori Morimoto(森本雍憲)

 

Development of a Computer Aided Information System to Provide Information of Adverse Effects to the Patient              47

Toshinari Endo(遠藤敏成), Nobuaki Kutsuma, Daisuke Kobayashi(小林大介),

Sachihiko Numajiri(沼尻幸彦), Hideo Ueda(上田秀雄), Fusao Komada(駒田富佐夫),

Yukiya Saitoh(齋藤侑也), and Yasunori Morimoto(森本雍憲)

 

Pharmacology and Toxicology

Sex hormone-regulated renal transport of perfluorooctanoic acid ----------------------------------------  48

Naomi Kudo(工藤なをみ),  Masanori Katakura (片倉賢紀), 

Yasunori Sato(佐藤靖典)and Yoichi Kawashima(川嶋洋一)

 

Mechanisms of Gastric Mucus Secretion from Cultured Rat Gastric Epithelial Cells Induced by Carbachol, Cholecystokinin Octapeptide, Secretin, and Prostaglandin E2------------------------------------------------------------------------------------  49

Satoru Tani(谷 覺), Teruo Suzuki(鈴木光生), Sayuri Kano(鹿野早夕里),  

Toru Tanaka,(田中 享) Katsuyosi Sunaga(須永克佳), Rie Morisige(森重利恵),  

and Tadashi Tsud(津田 整)

Postnatal changes in ghrelin mRNA expression and in ghrelin-producing cells in the rat stomach      50

I Sakata, T Tanaka(田中 享) , M Matsubara, M Yamazaki, S Tani(谷 覺),

Y Hayashi, K Kangawa and T Sakai

 

Trifluoromethyl Ketones Show Culture Age-dependent Inhibitory Effects on Low K+-induced Apoptosis in Cerebellar Granule Neurons--------------------------------------------------------------------------------------------------------------------------------------------------------  51

KATSUYOSHI SUNAGA(須永克佳), TORU TANAKA(田中 享), SATORU TANI(谷 覺)

and MASAMI KAWASE(河瀬雅美)

 

Nutraceutical

Administration of beta-carotene suppresses lipid peroxidation in tissues and improves the glucose tolerance ability of streptozotocin-induced diabetic rats.-------------------------------------------------------------------------------------------------  52

Furusho T, Kataoka E, Yasuhara T, Wada M(和田政裕), Innami S.

 

Dietary fiber suppresses elevations of uric acid and allantoin in serum and urine induced by dietary RNA and increases its excretion to feces in rats.------------------------------------------------------------------------------------------------------------------------  53

Koguchi T, Nakajima H, Wada M(和田政裕), Yamamoto Y, Innami S, Maekawa A, Tadokoro T.

 

Effects of dietary polyamines on the promotion of mammary tumor in rats. ---------------------------  54

Masahiro Wada(和田政裕), Ulala Funada-Wada, Hiroshi Mano(真野 博),

Mizuka Higashiguchi, Ryouta Haba, Shaw Watanabe, Shigezo Udaka

 

Effect of partially hydrolyzed curdlan on serum and hepatic cholesterol concentrations, and cecal fermentation in rats.        55

Jun Shimizu(清水 純), Masahide Oka, Keita Kudoh, Masahiro Wada(和田政裕),

Toshichika Takita, Satoshi Innami, Tadahiro Tadokoro, Akio Maekawa

 

Dietary curdlan suppresses dimethylhydrazine-induced aberrant crypt foci formation in Sprague-Dawley rats          56

Jun Shimizu(清水 純), Keita Kudoh, Masahiro Wada(和田政裕), Toshichika Takita,

Satoshi Innami, Akio Maekawa, Tadahiro Tadokoro

 

Clinical Nutritional

Effect of Soy Protein Intake on High-fat induced Obesity and Insulin resistance--------------------  57

Nobuyo Tsunoda角田伸代, Yuko Fujikane, Hyounju Kim金 賢珠,

Midori Ebata 江端みどり, Shinji Ikemoto池本真二

 

成人のタンパク質必要量に及ぼすエネルギー制限と肥満度の影響-------------------------------------------  58

池本真二(S. Ikemoto)、角田伸代(N. Tsunoda)、江端みどり(M. Ebata)、東口みづか

 

 

学長所管

平成13年度研究奨励金交付に伴う研究成果報告書

骨折及び骨粗鬆症の分子生物学的解析とその栄養学的予防法確立に関する研究------------------------  59

研究代表者  和田 政裕

 研究題目 医薬品の乳汁移行性予測に関する研究----------------------------------------------------------------------------  66

病院薬剤学講座 小林大介(Daisuke Kobayashi, 沼尻幸彦(Sachihiko Numajiri

 

口頭発表及びシンポジウム----------------------------------------------------------------------------------------------------  75

 

著書・総説・Proceedings-----------------------------------------------------------------------------------------------------------  96

 

学位論文要旨---------------------------------------------------------------------------------------------------------------------------------------- 101

高速気体を利用した薬物含有微粒子の皮内送達に関する研究-------------------------------------------------------- 103

  内田 昌希

水溶性高分子の鼻粘膜吸収に対するポリ-L-アルギニンの促進機構に関する研究------------------------ 106

大竹 一男

多成分油性基剤を用いた酸性薬物の皮膚透過促進に関する研究---------------------------------------------------- 108

方  亮

 

大学院薬学研究科修士論文要旨----------------------------------------------------------------------------------------- 111

薬学専攻

 ミセルを反応場とする両親媒性ヘリセンのキラリティーの誘起と変換---------------------------------------- 113

高市康宏

ヘリセンをプローブとするグリセロリン脂質二分子膜によるキラル識別------------------------------------ 113

吉田麻衣子

 結晶場によるキラリティーの制御 ―ラセミ結晶とエナンチオマー結晶―-------------------------------- 114

  吉野順

 IS-MSによるポリアミン分析法の癌研究への応用--------------------------------------------------------------------------- 115

小林正樹

 緊急安全性情報提供前後の塩酸チクロピジン処方動向調査------------------------------------------------------------ 116

石川 慎子 

 ポリオキシエチレン硬化ヒマシ油添加によるポリ塩化ビニル製輸液セットからの

ジエチルヘキシルフタレート溶出機構の検討------------------------------------------------------------------------------------ 116

数野 史  

 パップ剤の放出試験法の検討---------------------------------------------------------------------------------------------------------------- 117

向後 徹生  

 フレカイニドのTDMに用いる血中濃度測定法の開発と臨床応用------------------------------------------------- 118

中川 励  

 保険薬としての漢方製剤の問題点-------------------------------------------------------------------------------------------------------- 118

廣田 創   

 培養ラット胃粘膜上皮細胞における

粘液分泌機構の研究及びムチン遺伝子クローニングの試み................................................................................... 119

鹿野 早夕里 

 

著者索引-------------------------------------------------------------------------------------------------------------------------------------------------- 121