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＜電子ブック＞
Cancer Precursors : Epidemiology, Detection, and Prevention / edited by Eduardo L. Franco, Thomas E. Rohan
(Springer Texts in Statistics. ISSN:21974136)

版	1st ed. 2002.
出版者	(New York, NY : Springer New York : Imprint: Springer)
出版年	2002
本文言語	英語
大きさ	XX, 430 p : online resource
著者標目	Franco, Eduardo L editor Rohan, Thomas E editor SpringerLink (Online service)
件　名	LCSH:Oncology LCSH:Epidemiology LCSH:Medicine, Preventive LCSH:Health promotion LCSH:Cancer FREE:Oncology FREE:Epidemiology FREE:Health Promotion and Disease Prevention FREE:Cancer Biology
一般注記	Site-Specific Precancerous Conditions -- Biological Basis of Carcinogenesis -- Mechanisms and Biological Markers of Carcinogenesis -- Morphology of Cancer Precursor Lesions -- Issues Related to Measurement and Interpretation of Cancer Precursors -- Collection, Processing, and Analysis of Preneoplastic Specimens -- Intermediate Markers in Cancer Research: Theoretical and Practical Issues in the Use of Surrogate Endpoints -- Assessing Epidemiological Relations and the Role of Measurement Errors -- Site-Specific Precancerous Conditions -- Upper Aerodigestive Tract -- Esophagus -- Stomach -- Colon and Rectum -- Anus -- Liver -- Pancreas -- Lung -- Skin -- Breast -- Cervix -- Endometrium -- Ovary -- Vulva and Vagina -- Prostate -- Bladder -- Control of Cancer Precursors -- Screening -- Chemoprevention -- Evidence-Based Policy Recommendations on Screening and Prevention -- Conclusion -- Prospects Dramatic advances in our understanding of cancer causation have come from epidemiologic and laboratory research, particularly over the past two decades. These developments have included a broadening interest in the critical events that take place during the early stages of the dynamic multistep process leading to - vasive cancer. Increasingly, cancer epidemiologists are pursuing research into the origins and natural history of premalignant lesions, including intermediate or surrogate endpoints, a trend - celerated by the development of molecular technologies that are revolutionizing our understanding of the transformation of normal to malignant cells. There seems little doubt that this emerging knowledge will provide further insights not only into carcinogenic processes, but also into more sensitive methods of early detection and more effective means of prevention. In this book, Drs. Franco and Rohan have succeeded in prep- ing a comprehensive, timely, and critical review of the substantial progress that has been made in our understanding of cancer p- cursors. They have enlisted experts in the ?eld who have c- tributed authoritative chapters on the precursors to a wide variety of cancers,with emphasis on etiology and natural history,including the role of environmental and heritable factors that provoke normal cells to undergo malignant transformation. Epidemiologic data are linked whenever possible to molecular as well as classical cellular pathology, providing a fuller understanding of the causal events and mechanisms that initiate the carcinogenic process HTTP:URL=https://doi.org/10.1007/b97323

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