<電子ブック>
Fundamentals of Clinical Trials / by Lawrence M. Friedman, Curt D. Furberg, David L. DeMets
版 | 4th ed. 2010. |
---|---|
出版者 | New York, NY : Springer New York : Imprint: Springer |
出版年 | 2010 |
本文言語 | 英語 |
大きさ | XVIII, 445 p : online resource |
著者標目 | *Friedman, Lawrence M author Furberg, Curt D author DeMets, David L author SpringerLink (Online service) |
件 名 | LCSH:Biometry LCSH:Public health LCSH:Epidemiology LCSH:Cancer LCSH:Oncology FREE:Biostatistics FREE:Public Health FREE:Epidemiology FREE:Cancer Biology FREE:Oncology |
一般注記 | to Clinical Trials -- Ethical Issues -- What Is the Question? -- Study Population -- Basic Study Design -- The Randomization Process -- Blindness -- Sample Size -- Baseline Assessment -- Recruitment of Study Participants -- Data Collection and Quality Control -- Assessing and Reporting Adverse Events -- Assessment of Health-Related Quality of Life -- Participant Adherence -- Survival Analysis -- Monitoring Response Variables -- Issues in Data Analysis -- Closeout -- Reporting and Interpreting of Results -- Multicenter Trials This is the fourth edition of a very successful textbook on clinical trials methodology, written by three recognized experts who have long and extensive experience in all areas of clinical trials. Most chapters have been revised considerably from the third edition. A chapter on ethics has been added and topics such as noninferiority and adaptive designs now receive considerable discussion. There is much new material on adverse events, adherence, data monitoring, and issues in analysis. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials from a variety of medical disciplines to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan, and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful. This book has been successfully used for teaching courses in clinical trial methodology HTTP:URL=https://doi.org/10.1007/978-1-4419-1586-3 |
目次/あらすじ
所蔵情報を非表示
電子ブック | 配架場所 | 資料種別 | 巻 次 | 請求記号 | 状 態 | 予約 | コメント | ISBN | 刷 年 | 利用注記 | 指定図書 | 登録番号 |
---|---|---|---|---|---|---|---|---|---|---|---|---|
電子ブック | オンライン | 電子ブック |
|
|
Springer eBooks | 9781441915863 |
|
電子リソース |
|
EB00236858 |
書誌詳細を非表示
データ種別 | 電子ブック |
---|---|
分 類 | LCC:QH323.5 DC23:57,015,195 |
書誌ID | 4000119467 |
ISBN | 9781441915863 |
類似資料
この資料の利用統計
このページへのアクセス回数:2回
※2017年9月4日以降