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＜電子ブック＞
Bayesian Methods in Structural Bioinformatics / edited by Thomas Hamelryck, Kanti Mardia, Jesper Ferkinghoff-Borg
(Statistics for Biology and Health. ISSN:21975671)

版	1st ed. 2012.
出版者	(Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer)
出版年	2012
本文言語	英語
大きさ	XXII, 386 p : online resource
著者標目	Hamelryck, Thomas editor Mardia, Kanti editor Ferkinghoff-Borg, Jesper editor SpringerLink (Online service)
件　名	LCSH:Biometry LCSH:Medicine -- Research  全ての件名で検索 LCSH:Biology -- Research  全ての件名で検索 LCSH:Biophysics LCSH:Biomathematics LCSH:Bioinformatics FREE:Biostatistics FREE:Biomedical Research FREE:Biophysics FREE:Mathematical and Computational Biology FREE:Computational and Systems Biology
一般注記	Part I Foundations: An Overview of Bayesian Inference and Graphical Models -- Monte Carlo Methods for Inferences in High-dimensional Systems -- Part II Energy Functions for Protein Structure Prediction: On the Physical Relevance and Statistical Interpretation of Knowledge based Potentials -- Statistical Machine Learning of Protein Energetics from Experimentally Observed Structures -- A Statistical View on the Reference Ratio Method -- Part III Directional Statistics and Shape Theory: Statistical Modelling and Simulation Using the Fisher-Bingham Distribution -- Statistics of Bivariate von Mises Distributions -- Bayesian Hierarchical Alignment Methods -- Likelihood and Empirical Bayes Superpositions of Multiple Macromolecular Structures -- Part IV Graphical models for structure prediction: Probabilistic Models of Local Biomolecular Structure and their Application in Structural Simulation -- Prediction of Low Energy Protein Side Chain Configurations Using Markov Random Fields -- Part V Inferring Structure from Experimental Data -- Inferential Structure Determination from NMR Data -- Bayesian Methods in SAXS and SANS Structure Determination This book is an edited volume, the goal of which is to provide an overview of the current state-of-the-art in statistical methods applied to problems in structural bioinformatics (and in particular protein structure prediction, simulation, experimental structure determination and analysis). It focuses on statistical methods that have a clear interpretation in the framework of statistical physics, rather than ad hoc, black box methods based on neural networks or support vector machines. In addition, the emphasis is on methods that deal with biomolecular structure in atomic detail. The book is highly accessible, and only assumes background knowledge on protein structure, with a minimum of mathematical knowledge. Therefore, the book includes introductory chapters that contain a solid introduction to key topics such as Bayesian statistics and concepts in machine learning and statistical physics HTTP:URL=https://doi.org/10.1007/978-3-642-27225-7

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