CHEMICAL

―　Inorganic or Physical　―

Colloidal behavior of carrier-free 125mTe in aqueous solutions 1
Yasuko Yamaashi, Yoshiaki Maruyama

J. Radioanal. &　Naclear Chem., 231(1998), 63-64

Chirality Alteration of Racemic Thiaheterohelicenes with a Labile Helix Incorporated into Alkyl b -D-Pyranoside Micelles 3 7
Hiroko Nakagawa, Kanae Gomi, and Koh-ichi Yamada

Enantiomer, 3 (1998),175-179

Chromatography of Nucleosides on Copper(II)-Complexed b -Cyclodexitrin Polymer in Alkaline Medium 8
Hitomi Sasaki, Masaaki Ohara

Chem. Pharm. Bull., 46 (1998),1924-1925

―　Organic　―

Inhibitory Effects of Isoflavones in Roots of Astragalus membranaceus BUNGE (Astragali Radix) on Lipid Peroxidation by Reactive Oxygen Species 10
Shizuo Toda and Yoshiaki Shirataki

Phytotherapy Res., 12 (1998), 59-61

Isoflavonoids from Sophora Secundiflora, S. Arizonica and S. Gypsophila 13
Toshiyuki Tanaka, Masayoshi Ohyama, Munekazu Iinuma, Yoshiaki Shirataki, Manki

Komatsu, and Charles L. Burandt

Phytochmistry, 48 (1998), 1187-1193

　

AlCl3-mediated migration of the benzamido group of N-phenoxybenzamide derivatives to the phenyl group 20
E. Miyazawa, T. Sakamoto, and Y. Kikugawa

J. Chem. Soc., Perkin Trans, 2 (1998),7-11

Reaction of N-Phenoxyphthalimide Derivatives with Aluminum Chloride in Benzene 25
K. Uto, E. Miyazawa, K. Ito, T. Sakamoto, and Y. Kikugawa

Heterocycles, 48 (1998), 2593-2600

A General Method for the Peparation of 5-Trifluoromethylated Oxazoles From a -Amino Acids. 33
M. Kawase, H. Miyamae, and T. Kurihara

Chem. Pharm. Bull., 46 (1998), 749-756

The Dakin-West Reaction of N-Acyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acids using Trifluoroacetic Anhydride: Structural Revision for the Unexpected Product 41
M. Kawase, Y. Okada, and H. Miyamae

Heterocycles, 48 (1998), 285-294

Synthesis of 2-Trifluoromethyl-2,3,4,5-tetrahydro-1H-3-benzazepine Derivatives. 51 50
M. Kawase, M. Niwa, M. Nozaki, and N. Motohashi

Heterocycles, 48 (1998), 555-560

Trifluoroacetylation of Methylpyridines and Other Methylazines: A Convenient Access to Trifluoroacetonylazines. 57
M. Kawase, M. Teshima, S. Saito, and S. Tani

Heterocycles, 48 (1998), 2103-2109

Regioselective Reaction of Mesoionic 4-Trifluoroacetyl-1,3-oxazolium-5-olates with Phenylhydrazine: Synthesis of Trifluoromethyl Substituted Pyrazole and 1,2,4-Triazine Derivatives. 64
M. Kawase, H. Koiwai, A. Yamano, and H. Miyamae

Tetrahedron Lett., 39 (1998), 663-666

Origin of Regioselectivity in Nucleophilic Ring-Opening Reaction of 4-Trifluoroacetyl-1,3-oxazolium5-olates 68
M. Kawase, H. Koiwai, S. Saito, and T. Kurihara

Tetrahedron Lett., 39 (1998), 6189-6190

　

Biological Activity of 6,12-Dihydro-1-benzopyrano [3,4-b][1,4]benzothiazin-6-ones. 70

  1. Shah, Y. Naliapara, D. Sureja, N. Motohashi, T. Kurihara, M. Kawase, K. Satoh, H.Sakagami, and J. Molnar.

Anticancer Res., 18 (1998), 61-64

The Primary in vitro Antitumor Activity of “Half-Mustard Type” Phenothiazines in NCI’s Revised Anticancer Screening Paradigm. 71
M. A. Wuonola, M. G. Palfreyman, N. Motohashi, M. Kawase, S. Gabay, R. R.
Gupta, and J. Molnar.

Anticancer Res., 18 (1998), 337-348

Relationship between Radical Intensity and Cytotoxic Activity of Dopamine-related

Compounds. 72
M. Kawase, N. Motohashi, T. Kuihara, M. Inagaki, K. Satoh, and H. Sakagami

Anticancer Res., 18 (1998), 1069-1074

6,12-Dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones: Synthesis and mdr Reversal in Tumor Cells. 73
A. Shah, Y. Naliapara, D. Sureja, N. Motohashi, M. Kawase, C. Miskolci, D. Szabo,
and J. Molnar

Anticancer Res., 18 (1998), 3001-3004

Cyanoglycosylation products of 17-0-acetyltestosterone 74
Akihiko Tobari, Takanobu Shimizu, Hiroshi Miyamae, Akira Nagasawa, Masami
Kawase, and Setsuo Saito

Carbohydrate Res., 310 (1998), 239-252

An anomalous Dakin-West reaction of N-carbamate substituted prolines and trifluoroacetic ahydride. 88
Masami Kawase, Michitaka Hirabayashi, Hiromi Koiwai, Katsumi Yamamoto, and
Hiroshi Miyamae

Chem. Commun., (1998), 641-642

　

Nucleophilic Substitutions of 2-Chloronaphtho[2,3-b]furan-4,9-dione with Amines 90
Jyunichi Koyanagi, Masayuki Ogawa, Katsumi Yamamoto, Kouji Nakayama, and
Akira Tanaka

J. Heterocyclic.,Chem., 35 (1998), 301-305

Interaction Between Eugenol-Related Compounds and Radicals 95
Kazue Satoh, Hiroshi Sakagami, Ichiro Yokoe, Mutsuyuki Kochi, and Seiichiro
Fujisawa

Anticancer Res., 18 (1998), 425-428

Analytical

Studies on Inhibition of Enzymatic Arginyltransfer Reaction 96
Koichi Takao, Toshihisa Igarashi, Hironao Ogiso, Kazuya Ugata, Akira Shirahata, and Keijiro Samejima

Chem. Pharm. Bull., 46 (1998), 1169-1172

Unusual polyamines in aquatic plants: the occurrence of homospermidine, norspermidine, thermospermine, norspermine, aminopropylhomospermidine, bis(aminopropyl)ethanediamine, and methylspermidine 100
Koei Hamana, Masaru Niitsu, and Keijiro Samejima

Can. J. Bot., 76 (1998), 130-133

Ionspray Ionization-Mass Spectrometric Separation and Determination of Heptafluorobutyryl Derivatives of Polyamines 104
Naomi Furuumi, Daisuke Amano, Yong Ji Xu, Keijiro Samejima, Masaru Niitsu, and
Akira Shirahata

Analytical Biochemistry, 265 (1998), 253-259

Determination of perfluorinated carboxylic acids in biological samples by high-Performance liquid chromatography 111
Takeshi Ohya, Naomi Kudo, Erika Suzuki, and Yoichi Kawashima

J. Chromatogr. B, 720 (1998), 1-7

Determination of perfluorocarboxylic acids by gas-liquid chromatography in rat tissues 118
Naomi Kudo, Naoki Bandai, and Yoichi Kawashima

Toxicology Letters, 99 (1998), 183-190

Biological (Biochemical)

Structure and activity of mouse S-adenosylmethionine decarboxylase gene promoters and properties of the encoded proteins 126
Kazuhiro Nishimura, Marja Liisanantti, Yasuhide Muta, Keiko Kashiwagi, Akira
Shirahata, Marja Janne, katja Kankare, Olli A. Janne, and Kazuei Igarashi

Biochem．J., 332 (1998), 651-659

Comparison of the Effects of Gemfibrozil and Clofibric Acid on Peroxisomal Enzymes and Cholesterol Synthesis of Rat Hepatocytes 135
Fumie Hashimoto, Shoji Taira, and Hidenori Hayashi

Biol．Pharm. Bull., 21 (1998), 1142-1147

Synthetic Nucleosides and Nucleotides. 40. Selective Inhibition of Eukaryotic DNA Polymerase a By 9-(b -D-arabinofuranosyl)2-(p-n-butylanilino) adenine 5’-Triphosphate and Its 2’-up Azido Analog. 141
Aki Tomikawa, Masaki Seno, Kunie Sato-Kiyotaki, Chizuru Ohtsuki, Toshiaki Hirai,
Toyofumi Yamaguchi, Takeo Kawaguchi, Shonen Yoshida, and Mineo Saneyoshi

Nucleosides & Nucleotides, 17 (1998), 487-501〟

Pharmaceutical

Direct Transport of 2’,3’-Dihydro-3’-deoxythymidine (D4T) and Its Ester Derivatives to the Cerebrospinal Fluid via the Nasal Mucous Membrane in Rats. 142
Toshiyuki Yajima, Kazuhiko Juni, Mineo Saneyoshi, Tetsuya Hasegawa, and Takeo
Kawaguchi

Biol．Pharm. Bull., 21 (1998), 272-277

Thymidineの鼻粘膜透過に関する研究 148
Toshiyuki Yajima, Tetsuya Hasegawa, Kazuhiko Juni, Mineo Saneyoshi, and Takeo
Kawaguchi

Drug Delivery System, 13 (1998), 179-184

　

Effects of Cu, Zn-Superoxide Dismutase Delivered by Genetically Modified Skin Fibroblasts on Cold-Induced Skin Edema in Rats. 154
K. Nishiguchi, F. Komada, Y. Tanigawara, Y. Sakai, S. Iwakawa, and K. Okumura.

Biol．Pharm. Bull., 21 (1998), 1379-1381

Inhibitory Effects of a Cyclosporin Derivative, SDZ PSC 833, on Transport of Doxorubicin and Vinblastine via Human P-Glycoprotein. 157
N. Kusunoki, K. Takara, Y. Tanigawara, A. Yamauchi, K. Ueda, F. Komada, Y. Ku,
Y. Kuroda, Y. Saitoh, and K. Okumura

Jpn. J. Cancer Res., 89 (1998), 1220-1228 　

新規インスリンカートリッジ製剤の含有量均一性についてのバリデーション. 166
 駒田富佐夫・大道るみ・畑中久勝・谷川原祐介・奥村勝彦.

薬剤学，58(1998),164-169

A New In-situ Experimental Method to Evaluate the Cutaneous Disposition of Flurbiprofen After Topical Application in Hairless Rats 172
G. Yanagimoto, t. Hayashi, T. Seki, K. Juni, K. Sugibayashi, and Y. Morimoto

Pharm. Pharmacol. Commun., 4 (1998), 261-265

Constant Current and Constant Voltage Iontophoretic Transport of Morphine Hydrochloride through Hairless Rat Skin In-vitro 173
S. Numajiri, K. Sugibayashi, and Y. Morimoto

Pharm. Pharmacol. Commun., 4 (1998), 529-534

Effect of Several Hydrophilic Polymers on the Permeation of Morphine and Salicylic Acid through Excised Hairless Rat Skin 174
Osamu Hosoya, Motohiko Sano, Yoshio Wada, Toshinobu Seki, Kenji Sugibayashi,
Kazuhiko Juni, and Yasunori Morimoto

Chem. Pharm. Bull., 46 (1998), 882-885

Enhancing Effect of N-Acetyl-L-cysteine or 2-Mercaptoethanol on the in Vitro Permeation of 5-Fluorouracil or Tolnaftate through the Human Nail Plate 178
Yoichi Kobayashi, Misao Miyamoto, Kenji Sugibayashi, and Yasunori Morimoto

Chem. Pharm. Bull., 46 (1998), 1797-1802

脂溶性または水溶性薬物のみの皮膚透過性を促進する添加剤は存在するか？：数種促進剤を用いた検討 184
真鍋栄一郎・田中重男・杉林堅次・森本雍憲

薬剤学,　58 (1998), 10-16

Iontophoretic Transport of Morphine across Hairless Rat Skin: Is a Further Increase Obtained with Chemical Enhancer? 191
Sachihiko Numajiri, Hirohiko Inada, Kenji Sugibayashi, and Yasunori Morimoto

薬剤学,　58 (1998), 29-36

　

Pharmacological

Characteristics of Spontaneous Erythema Appeared in Hairless Rats 199
Satoru Tani, Makoto Noguchi, Yukihide Hosoda, Kenji Sugibayashi, and Yasunori
Morimoto

Exp. Anim., 47 (1998), 253-256

竜骨および牡蛎の薬理作用 203
津田 整・菅谷愛子・金子栄一・大口広美・加藤和美・金文・菅谷英一

Natural Medicines, 52 (1998), 300-309

Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. 213
M. Kimura, and M. Ogihara

Eur, J. Pharmacol., 354 (1998) 271-281

Expression of a 2-and b 2-adrenergic responses by hepatocyte growth factor and platelet-derived growth factor in primary cultures of adult rat hepatocytes. 224
M. Kimura, and M. Ogihara

Biol. Pharm. Bull., 21 (1998) 22-28

Proliferationof adult rat hepatocyes in primary cultures induced by platelet-derived growth factor is potentiated by phenylephrine. 231
M. Kimura, and M. Ogihara

Jpn. J. Pharmacol., 76 (1998) 165-174

紫外線照射によるSwiss 3T3細胞の障害及びプロスタグランジンE2遊離に対する漢方方剤四物湯の抑制作用 241
佐久間克也・小川雅之・木村光利・山本勝美・荻原政彦

薬学雑誌，118（1998），241-２４７

胎盤由来グルコセレブロシダーゼ（セレデース）によるGaucher病（II）型/(III)型の治療 248
北川照男・大和田操・成澤邦明・折居忠夫・衛藤義勝・岡田伸太郎・
鈴木義之・齋藤侑也・辻省次・難波栄二・大谷和正・鈴木保宏・岩井朝幸・
佐倉伸夫

　　小児科臨床，51 (1998)，1711-1737

胎盤由来のグルコセレブロシダーゼ（セレデース）によるゴーシュ（I）型の長期治療成績―治療時期別の投与量とその効果について― 275
北川照男・大和田操・成澤邦明・衛藤義勝・折居忠夫・鈴木義之・
岡田伸太郎・辻省次・齋藤侑也・大浦敏博・多喜紀雄・長嶋完二・島袋直哉

小児科臨床，51 (1998)，1859-1887

口頭発表及びシンポジウム 305

著書・総説・Proceedings類 316

学位論文要旨 319

大学院薬学研究科修士論文要旨 329

著者索引 343